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Recent studies using both in vitro and in vivo models indicate that glycyrrhizin directly targets and binds to the RNA-binding protein CUG-binding protein 1(CUGBP1), activating the Interferon (IFN)-/Signal Transducer and Activator of Transcription (STAT)1/Smad7 signaling pathway and thereby inhibiting HSC activation, ultimately exerting anti-fibrotic effects (Wu et al., 2016)

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Studies suggest that certain genetic variations may heighten the risk of depression in high-stress environments, while having little effect in low-stress settings [306]

doi:10.1007/s11655-015-2139-9

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