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However, their clinical translation is limited by potential limitations: 1) impaired tissue repair capacity due to senescent cell clearance, 2) off-target cytotoxicity to nonsenescent cells, and 3) transient inflammatory responses triggered by released cellular contents and inflammatory mediators

How do glutathione supplements support liver detoxification

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1 Five polyphenols that had been previously shown to induce apoptosis in leukaemia cells (quercetin, apigenin, emodin, rhein and cis- stilbene) 2 were combined with doxorubicin or etoposide in two lymphoid (CCRF-CEM and Jurkat) and two myeloid (THP-1 and KG1a) cell lines

Overall, suppository glutathione is a good middle ground between other options, but it needs more study before the true level of efficacy is determined