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however as the disease progresses, pathogens in the microbiome disable the immune response and immune exhaustion occurs (233, 234)

Gemcitabine Galactose-modified Gemcitabine also called senescence-specific killing compound 1 (SSK1) decreases senescent cells viability in multiple cell types, in mice and human in vitro models as well as in a broad range of inductions such as irradiation, replicative exhaustion, OIS and oxidative or genotoxic stress

Some patients report 6-12 months of improved function and reduced discomfort

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