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Liver samples from older patients (60-80 years) produced more fibrinogen than samples from younger donors (20-25 years), a pattern associated with chronic inflammation and age-related liver dysfunction

FPN is regulated by hepcidin, a hepatic-secreted peptide hormone, which promotes the internalization and degradation of FPN [74]

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These results indicate that SBA-15 MSN, and FA-SNCD@SBA-15 exhibit low cytotoxicity levels

Ca 2+ is a master regulator of eryptosis, mediating the Gardos effect-associated RBC dehydration and reduction of cell volume (cell shrinkage), calpain activation-mediated cytoskeleton remodeling (membrane blebbing), and PS externalization, which are major hallmarks of eryptosis