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A single targeted gamma-ray irradiation induced an acute modulation of immune cells and related cytokines in EMT6 mouse-bearing tumour model

reported that apoptotic extracellular vesicles released from residual liver tissue after PHx are cleared by circulating neutrophils, which increase the levels of progrowth factors such as HGF and FGF2 instead of proinflammatory cytokines to support regeneration in the liver remnant

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doi: 10.3390/biom11081224 59 LiangYLiuHFangYLinPLuZZhangPet al

These encourage formation of the more beneficial 2-OH-estrones, improve healthy estrogen metabolism, and help increase SHBG levels while discouraging formation of the more genotoxic estrogens