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The requirement of IGF-IR activation for skeletal muscle hypertrophy has been addressed in various models, such as overload-dependent or follistatin-induced muscle hypertrophy, showing conflicting findings 60,61

De Roos, A., Van Der Grond, J., Mitchell, G

By conjugating therapeutic peptides to these bone-targeting sequences, they can achieve higher local concentrations at the exact site where healing is needed while minimizing systemic exposure

Results showed: Significantly faster healing compared to controls Improved biomechanical properties of healed tendons Better collagen fiber organization Enhanced tensile strength Follow-up studies confirmed these findings and demonstrated that BPC-157 stimulated tendon cell (tenocyte) proliferation and migration in vitro