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These approaches hold the potential to overcome resistance mechanisms and enhance the effectiveness of existing therapies

large RCT outcome data is lacking for direct injection

In REDEFINE 1, adverse events were mainly gastrointestinal (79.6% in the CagriSema group vs 39.9% with placebo) including nausea (55% vs 12.6%), constipation (30.7% vs 11.6%), and vomiting (26.1% vs 4.1%)

The dulaglutide prescribing information states no dose adjustment is required for mild-to-moderate hepatic impairment but that clinical experience in this group remains limited

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