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If validated, this perspective could explain why so many single-agent trials of copper chelators or iron-chelating agents have failed to show dramatic clinical benefit

While the petitions grievances are specific to peptides, they reflect long-running criticisms of the FDA, which has often come under fire from patient advocacy groups who want better access to experimental treatments that might ease the progression of deadly diseases

As the innermost layer of the blood vessel wall, ECs are directly exposed to circulating blood, so they are easily injured by various risk factors and lead to their dysfunction and endothelial barrier damage (54)

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