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The thiol pK a of T(SH) 2 is 7.4, and hence significantly lower than that of GSH (Table 1) [45]

This functional loss may stem from age-related phagocytic exhaustion and the direct toxicity of iron-rich A and tau aggregates toward microglia (155) Furthermore, prior cell culture studies confirm that amyloid exposure accelerates microglial senescence (156)

Abstract Nuclear factor erythroid 2-related factor 2 (Nrf2) is a well-known transcription factor best recognised as one of the main regulators of the oxidative stress response

By lowering the body's overall inflammatory load, it could make the skin less reactive and less prone to the exaggerated inflammatory responses that turn a minor clogged pore into a major breakout

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