Type I IFNs act as a secondary signal to repress Cyp51a1 expression, leading to the accumulation of lanosterol, a precursor in the cholesterol biosynthetic pathway
Therefore, the conjunction of the immune checkpoint inhibitors to modulators of lipid peroxidation can have additive effect on immune responses and on the impact on tumour [278]
This has been dismissed by Chaplin [Chaplin, 2012] partly on the grounds that generation of osmotic pressure at aqueous interfaces might be a better explanation, and abhorrence of Pollacks use of the idea of 2-D hexagonal water clusters to explain his findings (this first appeared during the abortive debate over polywater more than forty years ago [Web reference 7], which was later debunked [Rousseau and Porto, 1970])
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