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The idea is straightforward: if GLP-1 therapy depletes B12, why not deliver both in one dose

In a randomized, double-blind Phase IIb study, effectiveness of this drug was shown in cirrhotic patients with evidence of a reduction of ammonia and a reduction in both the recurrence of HE and re-hospitalization [77]

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But clearly I think what the study showed was that this is a practice that's probably happening more often in Ontario than it should be happening." Silverstein, a recent graduate of medical school, remembered that little time was spent on the appropriate treatment of B12 deficiency