As a critical protein in the insulin signaling pathway, Akt activation is vital for normal insulin function: activated Akt regulates downstream targets to inhibit hepatic gluconeogenesis, promote cellular glucose uptake/utilization (maintaining blood glucose homeostasis), reduce hepatic glucose output via forkhead box O (FOXO) transcription factor inhibition, and enhance expression of genes like fatty acid synthase (FAS) to balance fatty acid synthesis and lipid metabolism
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Ibuprofen additionally shows anti-spore activity (median MIC 256 g/mL) and synergizes with amphotericin B, itraconazole, or terbinafine (Borba-Santos et al., 2021)
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