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Solid-phase peptide synthesis of D-amino acid chains of this length requires specialized reagents (D-Fmoc amino acids are significantly more expensive than their L-counterparts), extended synthesis times, and careful quality control to ensure correct sequence and sufficient purity

doi:10.1186/s13104-015-1437-9

327 , 371 , 445 , 446 , 451 , 452 Thus, while recent findings are promising, the social and economic burden of Alzheimer's and other dementias will continue to grow