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Others have reported 2,3-butanedione in refill fluids 15 and in EC aerosols 14 , also at relatively low concentrations

p53 is the most frequently mutated gene in human cancers and its mutations are associated with poor patient outcomes, although there is some controversy in lung cancer

"The main problem is that the carbon monoxide it produces in the body displaces oxygen from haemoglobin, the red blood cells that transport oxygen to the muscles in exercise," says Jackie Dabinett, director of the sport, performance and rehabilitation centre at Roehampton University