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Bibcode:2022Natur.605..349B

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For the chronic dosing studies, most studies are looking at doses of 4 g/day.[ref] (This used to be the maximum recommended acetaminophen dose per day, but that has now changed to 3g/day.) For reference, a single over-the-counter Extra Strength Tylenol is 500 mg, with the directions saying not to exceed 6 tablets in 24 hours (so 3g/day)

At the cellular level, DSIP has been associated with reduced markers of oxidative stress, improved mitochondrial function, and modulation of gene expression related to antioxidant defense

McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM