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Abdominal bloating can often be managed by ensuring adequate water intake throughout the day

A full discussion of risks and benefits is appropriate

10.1016/j.ucl.2021.12.003 121 QiaoL.HanM.GaoS.ShaoX.WangX.SunL.et al (2020)

When leucine levels rise, it reduces the activity of SEL1L, preventing the loss of important mitochondrial components

It is important to follow the prescribing doctors instructions carefully and not to stop the medication abruptly, as this can cause withdrawal symptoms