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What's missing: No human pharmacokinetic data No human safety data No optimal dose for humans (mouse 20mg/kg = ~150mg in a 75kg human if dose-equivalent, but mouse-to-human scaling for small molecules is unreliable) No drug interaction data No long-term safety data Buyers in this category are doing biohacker-tier self-experimentation with limited data

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Consistency is key: Take it at the same time every day to maintain steady levels

doi: 10.3390/nu14142858 23

Patients treated for dehydration from illness, exertion, or hangovers often feel immediate relief, including less dizziness, improved headache, and better thirst control within the same day