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5.2.2 Regulation of insulin resistance: pioglitazone Pioglitazone, a classic PPAR agonist, improves insulin sensitivity and alleviates systemic lipotoxicity by promoting adipocyte differentiation, enhancing adiponectin secretion, and reducing the expression of TNF - and MCP-1 (148)

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Cuprizone-induced demyelination in animals is accepted for studying multiple sclerosis-related lesions and is characterized by degeneration of oligodendrocytes more than by a direct attack on the myelin sheet (12)