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In addition to understanding the genetic underpinning of thyroid hormone delivery to tissues, associated future goals include developing more physiologic, sustained-release combination thyroid hormone therapies incorporating T3, and facilitating achievement of adequate thyroid hormone levels in all tissues

In addition, increasing TFAM levels enhanced mitochondrial DNA transcription and replication, aiding in the recovery of mitochondrial function, while boosting GPX4 levels directly reduced LPO buildup, thereby preventing ferroptosis

Due to its multiple amide groups and hydroxyl functionality, Dihexa possesses several potential hydrogen bond donors and acceptors