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Abstract We developed a novel enzymatic glutathione (GSH) production system using Saccharomyces cerevisiae as a whole-cell biocatalyst, and improved its GSH productivity by metabolic engineering

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HGH offers more potency and tighter dose control, but with nonphysiological exposure, endogenous suppression, higher cost and a heavier monitoring burden

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Taken together, these findings suggest an immunometabolic checkpoint that could be adopted as a pre-symptomatic biomarker and may also be therapeutically targeted alone or in combination with other immunotherapies for disease modification in AD