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(PDF) Abbreviations 5,10-methyleneTHF: 5,10-methylenetetrahydrofolate THF: tetrahydrofolate DHF: dihydrofolate dUMP: deoxyuridine monophosphate dTMP: deoxythymine monophosphate 5-methylTHF: 5-methyltetrahydrofolate cSHMT: cytosolic serinehydroxymethyl transferase mSHMT: mitochondrial serinehydroxymethyl transferase MTHFR: methylenetetrahydrofolate reductase TYMS: thymidylate synthase DHFR: dihydrofolate reductase Declarations Conflict of interest The authors have no conflict of interests related to this publication

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Curcumin Curcumin, chemically identified as 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, is the principal bioactive component derived from the rhizome of Curcuma longa L

04 Anti-Inflammatory (Calming Inflammaging) : It lowers the regulation of pro-inflammatory cytokines (TNF-, IL-6), alleviating low-grade chronic inflammation