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Thats one of the reasons large platforms are removing it
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Shahin M, Soudy R, Aliabadi HM, Kneteman N, Kaur K, Lavasanifar A
Together, these data suggested that the combined action of giredestrant with GPX4 inhibition is highly active across multiple ER+ cell lines, strikingly resembling the palbociclib-GPX4 inhibition synergy
A marked depletion of beneficial taxa was identified, including a significant reduction in Ligilactobacillusa probiotic genus important for mucosal immunityas well as a pronounced decrease in Butyrivibrio, a key butyrate producer essential for gut barrier integrity, and a substantial decline in [Eubacterium]_siraeum_group, which is involved in SCFA production
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