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For gut and nerve conditions, systemic SubQ or oral routes are appropriate

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Evidence includes: Stimulation of endothelial and keratinocyte migration Enhanced blood vessel density in wound healing models Promotion of stem cell differentiation toward repair cell lineages Low molecular weight enabling tissue penetration over long distances Unlike growth factors that bind to extracellular matrix, TB-500s mobility allows systemic distribution to multiple injury sites

Daily use for 12 weeks reportedly gives better results than sporadic use for 6 months