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Its mechanism is relevant to general visceral adiposity but no large RCT confirms equivalent effect in metabolically healthy adults

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It causes muscle weakness and rhabdomyolysis after hard exercise, fever, or prolonged fasting.[ref] CPT1 deficiency: There are two genes that encode the CPT1 gene: CPT1A and CPT1B

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Patients who wish to use resveratrol for its cardiovascular polyphenol effects should start at 100 to 250 mg/day, establish a blood-pressure baseline before starting, monitor twice daily for the first two weeks, and notify their prescriber if systolic pressure drops below 110 mmHg or symptoms develop