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COP1 Y491 and H578 form hydrogen bonds with c-Jun Q230 and M235 respectively

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The enterotrophic peptide hormone glucagon-like peptide 2 (GLP-2) was shown to abrogate OS and improve intestinal antioxidant capacity by reducing LPS-induced increases in intestinal IL-1 and oxidized glutathione levels (267) and increasing intestinal SOD activity and reduced-glutathione levels (268, 269) ( Supplementary Table 1 )

These medications work by inhibiting thyroid hormone synthesis, thereby helping to restore normal hormone levels and alleviate symptoms associated with this endocrine disorder