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One ME/CFS speciality clinic found 84% of 960 patients presented with at least one other comorbid condition, often resulting in worsened health ( Potential therapies Although some researchers have attempted to establish a treatment for ME/CFS and no reproducible results have been found (60), some treatments seem promising in ME/CFS ( Figure 13 )

RoB 2: a revised tool for assessing risk of bias in randomised trials

B-12 supports healthy sleep cycles, which can lead to deeper rest and easier mornings

Reported side effects are infrequent and mild: Mild headache or dizziness following administration

ACKNOWLEDGMENTS This work was supported in part by a grant from the Dutch government to the Netherlands Institute for Regenerative Medicine (NIRM, grant FES0908)