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Search strategy and study selection A systematic search was conducted up to November 2022 in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA), to identify original studies from the PubMed database (PubMed, 2006) investigating GSH levels in (i) brain in vivo, using proton MRS ( 1 H-MRS) of healthy adults, or ex vivo biochemical analyses of autopsy tissue from people without neurological or psychiatric conditions in life, and/or (ii) blood from healthy adults using biochemical analyses of the fluid component (i.e., plasma or serum)

PLoS ONE 13 , e0195166 (2018)

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Certain GSTs like BZ-2 has been identified to catalyze the formation of anthocyanin-GSH conjugates, which allows transport into vacuoles thus reducing the cytotoxic effects of higher anthocyanin concentrations (Marrs et al., 1995)

Prevention and Management: Most patients dont want to prevent this side effect and its their actual intended goal