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178 Inducing ferroptosis may be an important therapeutic strategy to reverse drug resistance in GBM with high expression of Nrf2 and ABCC1

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10.1006/jmbi.1999.3110 710 WthrichK

Baseline: CBC, B12, folate, iron studies Repeat B12 levels 1 month after loading dose Annual checks for chronic therapy Monitor potassium during initial treatment Neurological exams for neuropathic symptoms B12 injections can "mask" megaloblastic anemia from folate deficiency while allowing neurological damage to progress