The amount of HGF inhibitor that is administered may be in the range of from about 0.1 to about 1 ,000 mg/kg, an preferably in the range of from about 1 to about l OOmg/kg, although as one of skill in the art will recognize, the precise amount may vary depending on one or more attributes of the drug recipient, including but not limited to: weight, overall health, gender, age, nationality, genetic history, other conditions being treated, etc., and larger or smaller doses are within the practice of this invention
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It induces glutathione (GSH) synthesis and attenuates GSH depletion in lung epithelial cells during the oxidative stress [103]
By hitting these secondary endpoints so strongly against apremilast, Takeda is positioning zasocitinib to fundamentally disrupt the first-line oral and tier-preferred immunology market
