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doi: 10.3390/jcm10040562

HJS and HS have equally contributed to the completion of this work as the first authors

Key Nutrients Depleted by Corticosteroids Corticosteroids are associated with depletion of multiple nutrients essential for tissue repair, immune defense, and metabolic stability, including: Calcium, vitamin D, magnesium, potassium, zinc, selenium, vitamin C, and protein (1) Mechanisms of Steroid-Induced Nutrient Depletion Calcium & vitamin D: Reduced intestinal absorption and increased urinary loss osteopenia and fracture risk Zinc, selenium & vitamin C: Impaired immune function, delayed wound healing, increased infection risk Protein: Accelerated protein breakdown muscle wasting and connective tissue weakness Magnesium & potassium: Electrolyte imbalance fatigue, weakness, and cardiac rhythm disturbances Why Steroid-Induced Nutrient Depletion Impairs Healing By chronically elevating cortisol signaling, corticosteroids shift the body into a catabolic, stress-dominant state

10.1124/mi.3.2.90 Mol