Zhang W, Doherty M, Bardin T, et al
doi: 10.3389/fncel.2025.1601366 Received 27 March 2025 Accepted 10 June 2025 Published 04 July 2025 Volume 19 - 2025 Edited by Marco Cambiaghi, University of Verona, Italy Reviewed by Enoch Luis, National Council of Science and Technology (CONACYT), Mexico Mingzi Zhang, University of Southern California, United States Updates Copyright 2025 Bessetti and Litwa
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this passive diffusion mechanism, which is though very limited for drug delivery purposes, is commonly used by highly lipid soluble substances with molecular weights less than 400500 Da, or small hydrophilic molecules such as sucrose (Wong et al., 2019)
But this also means increasing intake of other key antioxidants like alpha-lipoid acid (ALA) to reduce oxidative stress and thus reduce demand for GSH