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Under this dual assault of energy metabolism impairment and membrane structural damage, synapses emerge as vulnerable early targets of ferroptosis, providing a mechanistic basis for the cognitive alterations observed in the preclinical stages of AD

The general consensus is that aged fibroblasts are more prone to senescence with decreased proliferation with a reduced ability to respond to growth factors [159161]

Deconjugation As related to the mercapturate pathway, deconjugation is defined as the removal of the intact cysteine-containing moiety (usually as GSH) from the thioether conjugate (Stevens and Jones, 1989)

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