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Bolcato, G

They observed that compared to the controls, the total antioxidant status was decreased, total oxidant status was increased, and markers of apoptosislike PARP-1 and Caspase-3 were elevated in the CBZ-treated group, leading to their conclusion that renal toxicity due to CBZ treatment occurs through oxidative stress-mediated apoptosis 19

In this context, GLA-mutant kidney organoids can also be applied for high-throughput screening systems for Fabry disease

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