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Materials and methods Human brain tissue and neuropathology The use of post-mortem brain tissues from the BRAIN cohort (Brain Research in Aging, Inflammation and Neurodegeneration) was evaluated by the METc (nr 2021/496) on August 31, 2021, concluding that the protocol is not clinical research with humans as meant in the Medical Research Involving Human Subjects Act

During the aging process, the expression of NRF2dependent antioxidant enzymes decreases, thereby leading to oxidative stress and related diseases [176]

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Cigarette smoking is a public health problem thats responsible for preventable chronic diseases and premature death