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Moreover, exposure of cancer cells to stimuli such as hypoxia, radiation and chemotherapy causes cell damages and leads to protein degradation, resulting in increased levels of TCA cycle intermediates and in an enhanced haem biosynthesis 49,50

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J Comp Pathol 206:18 Condorelli RA, La Vignera S, Mongio LM, Alamo A, Giacone F, Cannarella R, Calogero AE (2019) Thyroid hormones and spermatozoa: in vitro effects on sperm mitochondria, viability and DNA integrity