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Oxidative stress is implicated in endothelial dysfunction, which underlies many cases of vascular ED

2018, 62, e01849-17 10.1128/AAC.01849-17

Aguilar-Dorado IC, Hernndez G, Quintanar-Escorza MA, Maldonado-Vega M, Rosas-Flores M, Caldern-Salinas JV

Effects seen at those exposures cannot be assumed to occur at physiologic levels, and pushing systemic exposure high enough to reproduce them in a whole organism is precisely what raises the copper-loading concern