In contrast, Ms4a15 knockout cells showed no viability change
10.3389/fphys.2020.00935 Summary Keywords acute kidney injury (AKI), energy metabolic reprogramming, mitochondrial dysfunction, proximal tubular cells (PTC), therapeutic implications Citation Cao M, Zhao X, Xia F, Shi M, Zhao D, Li L and Jiang H (2025) Mitochondrial dysfunction and metabolic reprogramming in acute kidney injury: mechanisms, therapeutic advances, and clinical challenges
SOD catalyzes the conversion of superoxide radicals into hydrogen peroxide, which is then further detoxified by catalase and glutathione peroxidase
A key translational challenge will be to define the threshold and heterogeneity of GSH abundance across tumor types and microenvironmental niches, as this may critically influence treatment selectivity and resistance
not approved