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395 In a mouse model of diet-induced NASH and a rat model of thioacetamide (TAA)-induced liver fibrosis, CCR2/5 antagonists (Cenicriviroc, CVC) effectively reduced fibrosis as measured by reducing protein expression of collagen I and -SMA, and collagen deposition in the region around the liver lobules by targeting hepatic-pathogenic monocytes/macrophages and HSCs

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Beneath the intestinal epithelium resides the lamina propria that contains innate and adaptive immune cells, including macrophages, regulatory T cells, B cells, neutrophils, dendritic cells, plasma cells, and mast cells, protecting against microorganisms that penetrate the epithelium