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Notably, Ang-2 induced the upregulation of 2 -integrin on monocytes, which interacted with ICAM-1 expressed by endothelial cells and thereby facilitated the migration of monocytes, leading to accumulation of monocyte-derived macrophages in the TME (77)

In confirmation of this finding, Khani et al

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Semaglutide or Tirzepatide: GLP-1 receptor agonists work through entirely different mechanisms (appetite suppression, glucose regulation, delayed gastric emptying) compared to AOD-9604s direct lipolytic effects