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Larazotide has been specifically tested in the setting of celiac disease, but a combination of the three has never been studied in either animal or human trials

Funding This work was financially supported by the National Natural Science Foundation of China (82373955), the Natural Science Foundation from Guangdong Science and Technology Department of China (2023A1515012633), the Science and Technology Program of Guangzhou (202201011600) and the Dean's Fund (YQ202302)

Several unanswered questions remain regarding: Long-term receptor adaptation Extended safety observations Pharmacokinetic variability Biological mechanisms Combination pathway interactions These questions are common during the development of novel peptide-based compounds

These mechanisms come largely from rodent models and have not been confirmed in dogs

The ideal temperature range is between 2C and 8C (36F and 46F)