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7 A similar outcome from nicotine salts was observed in the current study: among adolescents who reported exclusively vaping, nicotine exposure was highest among those who reported using nicotine salt e-liquids

Chronic nicotine use dysregulates this system, increasing stress sensitivity and emotional instability over time. Additionally, Mendelian randomization studies have found causal evidence that smoking increases the risk of developing depression and even schizophrenia, rather than simply being a consequence of them. This supports the view that smoking may not only sustain but also exacerbate or even initiate mood disorders in vulnerable individuals

Exposure to the e-liquids also increased the relative levels of reactive oxygen species - molecules that can cause DNA damage - and the levels of molecules associated with programmed cell death

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