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Due to light absorption, exposure to oxygen tension, and high metabolic and energy demands, the retina is an environment highly susceptible to the formation of ROS, including oxidants and free radicals, which damage cellular proteins and lipid membranes 1,2,3,4

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Its Vitamin B12 also plays a key role in reducing levels of an amino acid called homocysteine, high levels of which have been linked to chronic conditions like heart disease, stroke, and Alzheimers

MTHFR gene polymorphism and age of onset of schizophrenia and bipolar disorder

Cagrilintide's published rationale begins from these two constraints