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A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient

However, over-dosing can promote excess growth or result in unwanted byproducts

As more people discover the transformative benefits of targeted nutrient therapy, vitamin injections have become a powerful tool in the journey toward optimal health and fitness

Fatigue also emerged as one of the most frequently discussed complaints

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