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Most peptides degrade rapidly when exposed to stomach acid or digestive enzymes

2016;103(3):942-951.doi:10.3945/ajcn.115.115188 Maares M, Haase H

Moreover, Tet3-KD neurons or Tetrodotoxin-induced decreases in Tet3 expression exhibited increased CpG methylation at the BDNF promoter IV region, whereas bicuculline-induced increases in Tet3 expression were shown to be associated with decreased methylation at the same region, supporting a pivotal role of Tet3 in regulating gene expression in response to global synaptic activity changes [54]

& Grndling, A

Moreover, many of the early studies linking AIFM2 to apoptosis relied on predictive models, lacked apoptosis-specific markers or failed to demonstrate functional rescue using apoptosis inhibitors