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Summary Proper functioning of the musculoskeletal system, muscles, as well as the elasticity and continuity of our skin is essential for the comfort of our lives

For example, a major age-associated feature of NSCs is the deterioration of protein quality control, including autophagy-lysosome function, chaperone activity, and overall aggregate processing

Feature C of Criterion 2 (chronic pain and/or instability) cannot be counted towards a diagnosis of hEDS in this situation

Indeed, we demonstrated that GSH finely compensates the decline of SOD1 activity in: (i) cells expressing less active SOD1 mutant found in familial amyotrophic lateral sclerosis (Vigilanza et al., 2008)

Human detection data is more limited