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Patients already avoiding steroids due to hepatic or renal concerns should be evaluated carefully, as the combined metabolic load of an aggressive peptide protocol warrants individual assessment

Peptides can potentially improve symptoms, strengthen the skin barrier, and reduce inflammation, but they do not alter the underlying genetic predisposition

It appears that these beneficial effects all together provide a particular network reflecting activity of a special peptidergic defence system

In the Phase 2 clinical trial (NEJM, 2023), retatrutide was administered subcutaneously at doses ranging from approximately 0.5 mg to 12 mg per week, with dose escalation under close medical supervision

A smaller needle also means less tissue damage and less scarring over time