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So far, very few research papers have been reported on the immunological response after metal NPs treatment to PBMC cells

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Diagnostic value of serum IGF-1 and IGFBP-3 in growth hormone deficiency: A systematic review with meta-analysis

The 2010s introduced gene-expression analysis: data generated through the Broad Institute's Connectivity Map indicated that GHK exposure modulated expression of 4,192 of the 13,424 human genes assayed, with approximately equal up- and down-regulation across stress-response, inflammation, and tissue-repair pathways [2]