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[17] At steady state, plasma cotinine levels are determined by the amount of cotinine formation and the rate of cotinine removal, which are both mediated by the enzyme CYP2A6

Why it matters: Tobacco use remains the leading cause of preventable death in the U.S., killing close to 500,000 Americans every year

Report Details How Trump Did Big Tobaccos Bidding on Flavored Vapes Despite Risk to Kids "Trump could not care less about the health consequences and costs of giving teenagers access to addictive flavored poison if it means his tobacco industry donors can make record profits," said one public health advocate

[1] When sales and imports were placed on hold on November 29, 2021 due to a patent dispute with British American Tobacco, the devices were sold at at least 52 flagship stores in malls, mobile units (sometimes in parking lots of convenience stores) and kiosks, as well as pop-up stores inside convenience stores