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In our previous study, pegylated arginase I treatment may reduce OTC protein expression in human T-ALL cell lines and also hMSCs [153]

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The brain is particularly vulnerable to oxidative damage due to its high oxygen consumption, abundant lipid content, and relatively low antioxidant capacity [151]

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Moreover, targeting SCD1/NRF2 to overcome FLT3-ITD resistance [174], Cystine uptake inhibition in NPM1-mutated AML [14], and inhibiting GPX4/SLC7A11 pathways in IDH-mutant disease could overcome drug resistance in leukemia