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Interestingly, there is a gender difference in response to GH treatment with men being more responsive in terms of IGF-I generation and fat loss during therapy, most probably due to men having lower estrogen levels that negatively impact the effect of GH on IGF-I generation in the liver (38)

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These researchers discovered that castration caused 4-hydroxynonenal and 8-hydroxy-20-deoxy-guanosine protein adducts in the regressing epithelium, which suggests oxidative damage